Assay Detail
Functional
CHEMBL4145133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild-type HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days in presence of 50 % of human serum by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.24 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300891 | — | — | 1 | 6.94 |
| CHEMBL414640 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300891 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL414640 | — | EC50 | = | 2881.0 | nM | 5.54 |