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Assay Detail

CHEMBL4145237

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HBV genotype D infected in human HepG2.2.15 cells assessed as inhibition of viral DNA level treated twice for 3 days measured after 6 days by real time PCR
73
Total Activities
68
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism hepatitis B virus genotype D
Confidence 1 — Organism
Curated By Intermediate

Target

HBV genotype D (CHEMBL612769)
Type ORGANISM
Organism hepatitis B virus genotype D

Publication

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).
Vandyck K, Rombouts G, Stoops B, Tahri A, Vos A, Verschueren W, Wu Y, Yang J, Hou F, Huang B, Vergauwen K, Dehertogh P, Berke JM, Raboisson P.
J Med Chem (2018) 61 : 6247 -6260
PubMed 29906396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 68 5.82 7.16
Activity 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4163671 1 7.16
CHEMBL4170274 1 7.03
CHEMBL4166873 1 7.00
CHEMBL4174774 1 6.96
CHEMBL4170099 1 6.92
CHEMBL4159471 1 6.92
CHEMBL4173963 1 6.68
CHEMBL4163019 1 6.57
CHEMBL4159644 1 6.55
CHEMBL4167378 1 6.54
CHEMBL4166173 1 6.51
CHEMBL4170524 1 6.50
CHEMBL4163010 1 6.47
CHEMBL4166164 1 6.44
CHEMBL4174998 1 6.42
CHEMBL4174246 1 6.33
CHEMBL4167428 2 6.30
CHEMBL4166289 1 6.27
CHEMBL1734714 2 6.22
CHEMBL4160850 1 6.18
CHEMBL4174636 2 6.18
CHEMBL4161956 1 6.13
CHEMBL4170270 1 6.12
CHEMBL4159641 1 6.12
CHEMBL4171468 1 6.11
CHEMBL4167121 1 6.09
CHEMBL4171311 1 6.08
CHEMBL4163941 1 6.03
CHEMBL4162833 1 6.02
CHEMBL4159523 2 5.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4163671 EC50 = 70.0 nM 7.16
CHEMBL4170274 EC50 = 93.0 nM 7.03
CHEMBL4166873 EC50 = 100.0 nM 7.00
CHEMBL4174774 EC50 = 110.0 nM 6.96
CHEMBL4170099 EC50 = 120.0 nM 6.92
CHEMBL4159471 EC50 = 120.0 nM 6.92
CHEMBL4173963 EC50 = 210.0 nM 6.68
CHEMBL4163019 EC50 = 270.0 nM 6.57
CHEMBL4159644 EC50 = 280.0 nM 6.55
CHEMBL4167378 EC50 = 290.0 nM 6.54
CHEMBL4166173 EC50 = 310.0 nM 6.51
CHEMBL4170524 EC50 = 320.0 nM 6.50
CHEMBL4163010 EC50 = 340.0 nM 6.47
CHEMBL4166164 EC50 = 360.0 nM 6.44
CHEMBL4174998 EC50 = 380.0 nM 6.42
CHEMBL4174246 EC50 = 470.0 nM 6.33
CHEMBL4167428 EC50 = 500.0 nM 6.30
CHEMBL4166289 EC50 = 540.0 nM 6.27
CHEMBL1734714 EC50 = 600.0 nM 6.22
CHEMBL4174636 EC50 = 660.0 nM 6.18
CHEMBL4160850 EC50 = 660.0 nM 6.18
CHEMBL4161956 EC50 = 740.0 nM 6.13
CHEMBL4170270 EC50 = 750.0 nM 6.12
CHEMBL4159641 EC50 = 750.0 nM 6.12
CHEMBL4171468 EC50 = 780.0 nM 6.11
CHEMBL4167121 EC50 = 810.0 nM 6.09
CHEMBL4171311 EC50 = 830.0 nM 6.08
CHEMBL4163941 EC50 = 930.0 nM 6.03
CHEMBL4162833 EC50 = 960.0 nM 6.02
CHEMBL4159523 EC50 = 1040.0 nM 5.98
CHEMBL4169186 EC50 = 1100.0 nM 5.96
CHEMBL4170775 EC50 = 1180.0 nM 5.93
CHEMBL4161261 EC50 = 1200.0 nM 5.92
CHEMBL4173717 EC50 = 1240.0 nM 5.91
CHEMBL4159872 EC50 = 1400.0 nM 5.85
CHEMBL4170963 EC50 = 1700.0 nM 5.77
CHEMBL4163422 EC50 = 1990.0 nM 5.70
CHEMBL4163416 EC50 = 2100.0 nM 5.68
CHEMBL4162883 EC50 = 2230.0 nM 5.65
CHEMBL4176489 EC50 = 2220.0 nM 5.65
CHEMBL4171559 EC50 = 2330.0 nM 5.63
CHEMBL4164684 EC50 = 2600.0 nM 5.58
CHEMBL4162188 EC50 = 2740.0 nM 5.56
CHEMBL4174338 EC50 = 3060.0 nM 5.51
CHEMBL4165879 EC50 = 3630.0 nM 5.44
CHEMBL4173724 EC50 = 4180.0 nM 5.38
CHEMBL4171318 EC50 = 4500.0 nM 5.35
CHEMBL4177085 EC50 = 4530.0 nM 5.34
CHEMBL4169882 EC50 = 5020.0 nM 5.30
CHEMBL4174590 EC50 = 5300.0 nM 5.28