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Target Snapshot

CHEMBL612769 Target Snapshot

HBV genotype D · ORGANISM · hepatitis B virus genotype D

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79Compounds
58Assays
2Approved Drugs
79.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HBV genotype D as ChEMBL target CHEMBL612769. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HBV genotype D
ORGANISM · hepatitis B virus genotype D
As of 2026-09-13
ChEMBL target ID
CHEMBL612769
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HBV genotype D still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHBV genotype D
Target TypeORGANISM
Organismhepatitis B virus genotype D
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHBV genotype D
UniProt AccessionN/A

HBV genotype D

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HBV genotype D.

Review nameHBV genotype D
Organismhepatitis B virus genotype D
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

EC5079.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5314362 8.42 EC50 3.8 Approved
CHEMBL4520436 7.72 EC50 19.0 Preclinical
CHEMBL4439062 7.54 EC50 29.0 Preclinical
CHEMBL141 7.52 EC50 30.0 Approved
CHEMBL4446304 7.34 EC50 45.7 Preclinical
CHEMBL4163671 7.16 EC50 70.0 Preclinical
CHEMBL4170274 7.03 EC50 93.0 Preclinical
CHEMBL4166873 7.0 EC50 100.0 Preclinical
CHEMBL4174774 6.96 EC50 110.0 Preclinical
CHEMBL4159471 6.92 EC50 120.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
15
5.5
20
6.0
11
6.5
4
7.0
4
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ENTECAVIR
CHEMBL5314362
Approved 2005
Properties Compare Identifier
LAMIVUDINE
CHEMBL141
Approved 1995
Properties Compare Identifier
Assay Landscape

Assay Landscape

58
Total Assays
71
Tested Compounds
1
Assay Types
Functional — 58 assays, 71 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 58 71 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine