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Compound Detail

CHEMBL4520436

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Nc1ncnc2c1ncn2[C@H]1C=C(F)[C@H](CO)[C@H]1CO

Basic Information

ChEMBL ID CHEMBL4520436
Phase Preclinical
Structure Type MOL
InChI Key NIKWTRQGSKSOFO-BHNWBGBOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

279.3
MW (Da)
0.03
ALogP
7
HBA
3
HBD
110.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H14FN5O2
MW 279.27
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness 0.51

Activity Summary

EC50 1 meas. best 7.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HBV genotype D
CHEMBL612769
EC50 7.72 7.72 19.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
HBV genotype D EC50 = 19.0 nM 7.72 Antiviral activity against HBV genotype D infected in human HepG2.2.15 cells ass... 30613328

Literature References

PubMed DOI Target Context # Activities
30613328 10.1021/acsmedchemlett.8b00374 MT2 1
30613328 10.1021/acsmedchemlett.8b00374 Human immunodeficiency virus 1 1
30613328 10.1021/acsmedchemlett.8b00374 HBV genotype D 1
30613328 10.1021/acsmedchemlett.8b00374 HepG2 2.2.15 1
30613328 10.1021/acsmedchemlett.8b00374 Unchecked 1

Data from ChEMBL 36 via Core Engine