Assay Detail
Functional
CHEMBL4145348
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Antiviral activity against Ebolavirus infected in human HuH7 cells after 48 hrs by immunofluorescence assay
13
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 5 | - | - |
| EC50 | 5 | 5.43 | 5.70 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159994 | — | — | 3 | 5.70 |
| CHEMBL4172550 | — | — | 2 | 5.61 |
| CHEMBL4174075 | — | — | 3 | 5.56 |
| CHEMBL4163357 | — | — | 3 | 5.36 |
| CHEMBL3425867 | — | — | 2 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159994 | — | EC50 | = | 2001.0 | nM | 5.70 |
| CHEMBL4172550 | — | EC50 | = | 2436.0 | nM | 5.61 |
| CHEMBL4174075 | — | EC50 | = | 2728.0 | nM | 5.56 |
| CHEMBL4163357 | — | EC50 | = | 4345.0 | nM | 5.36 |
| CHEMBL3425867 | — | EC50 | = | 11860.0 | nM | 4.93 |
| CHEMBL4163357 | — | Activity | - | — | - | |
| CHEMBL4174075 | — | Activity | - | — | - | |
| CHEMBL4159994 | — | Activity | - | — | - | |
| CHEMBL4172550 | — | EC90 | = | 7.732 | uM | - |
| CHEMBL4163357 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4174075 | — | EC90 | = | 8.062 | uM | - |
| CHEMBL4159994 | — | EC90 | = | 7.865 | uM | - |
| CHEMBL3425867 | — | EC90 | = | 21.91 | uM | - |