Assay Detail
Functional
CHEMBL4145427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human SSTR3 expressed in HEK293 cells assessed as [Tyr1]-somatostatin 14-induced beta-arrestin recruitment pre-incubated for 30 mins before [Tyr1]-somatostatin 14 stimulation for 90 or 180 mins by chemiluminescence method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.36 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168948 | — | — | 1 | 5.51 |
| CHEMBL4163618 | — | — | 1 | 5.21 |
| CHEMBL4173913 | — | — | 1 | - |
| CHEMBL4174297 | — | — | 1 | - |
| CHEMBL4161021 | — | — | 1 | - |
| CHEMBL4165525 | — | — | 1 | - |
| CHEMBL4176134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168948 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4163618 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL4173913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4174297 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4161021 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4165525 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4176134 | — | IC50 | > | 20000.0 | nM | - |