Assay Detail
Functional
CHEMBL4146245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BAF3 cells harboring CD74-ROS1 after 72 hrs by SRB or CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.14 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168868 | — | — | 1 | 9.70 |
| CHEMBL3286830 | LORLATINIB | 4.0 | 1 | 8.92 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.31 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168868 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3286830 | LORLATINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 48.6 | nM | 7.31 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 234.0 | nM | 6.63 |