Assay Detail
Binding
CHEMBL4146836
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Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every minute for 10 mins by Ellman's method
59
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 6.85 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165327 | — | — | 1 | 9.44 |
| CHEMBL4159705 | — | — | 1 | 8.57 |
| CHEMBL4161065 | — | — | 1 | 8.00 |
| CHEMBL4163678 | — | — | 1 | 7.96 |
| CHEMBL4173239 | — | — | 1 | 7.78 |
| CHEMBL4165973 | — | — | 1 | 7.74 |
| CHEMBL4169938 | — | — | 1 | 7.68 |
| CHEMBL4159880 | — | — | 1 | 7.65 |
| CHEMBL4162015 | — | — | 1 | 7.62 |
| CHEMBL4177133 | — | — | 1 | 7.53 |
| CHEMBL4173784 | — | — | 1 | 7.43 |
| CHEMBL4168037 | — | — | 1 | 7.37 |
| CHEMBL4160115 | — | — | 1 | 7.26 |
| CHEMBL4159243 | — | — | 1 | 7.16 |
| CHEMBL4166513 | — | — | 1 | 7.15 |
| CHEMBL4168987 | — | — | 1 | 6.96 |
| CHEMBL4170331 | — | — | 1 | 6.93 |
| CHEMBL4165562 | — | — | 1 | 6.84 |
| CHEMBL4171568 | — | — | 1 | 6.77 |
| CHEMBL4160696 | — | — | 4 | 6.76 |
| CHEMBL4176179 | — | — | 1 | 6.68 |
| CHEMBL4164981 | — | — | 1 | 6.62 |
| CHEMBL4175003 | — | — | 1 | 6.56 |
| CHEMBL4173405 | — | — | 1 | 6.51 |
| CHEMBL4166464 | — | — | 1 | 6.42 |
| CHEMBL4172353 | — | — | 1 | 6.25 |
| CHEMBL4172797 | — | — | 1 | 6.25 |
| CHEMBL4174372 | — | — | 1 | 6.05 |
| CHEMBL4173313 | — | — | 1 | 6.05 |
| CHEMBL4160310 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165327 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4159705 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4161065 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4163678 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4173239 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL4165973 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL4169938 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4159880 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL4162015 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4177133 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL4173784 | — | IC50 | = | 37.1 | nM | 7.43 |
| CHEMBL4168037 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4160115 | — | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL4159243 | — | IC50 | = | 69.3 | nM | 7.16 |
| CHEMBL4166513 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4168987 | — | IC50 | = | 110.5 | nM | 6.96 |
| CHEMBL4170331 | — | IC50 | = | 116.5 | nM | 6.93 |
| CHEMBL4165562 | — | IC50 | = | 143.5 | nM | 6.84 |
| CHEMBL4171568 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4160696 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4176179 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4164981 | — | IC50 | = | 242.4 | nM | 6.62 |
| CHEMBL4175003 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4160696 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL4173405 | — | IC50 | = | 307.5 | nM | 6.51 |
| CHEMBL4166464 | — | IC50 | = | 378.8 | nM | 6.42 |
| CHEMBL4160696 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL4172353 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL4172797 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL4173313 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL4174372 | — | IC50 | = | 893.8 | nM | 6.05 |
| CHEMBL4160310 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL4160696 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL4170940 | — | IC50 | = | 1861.0 | nM | 5.73 |
| CHEMBL4101303 | — | IC50 | = | 5339.0 | nM | 5.27 |
| CHEMBL4163016 | — | IC50 | = | 9267.0 | nM | 5.03 |
| CHEMBL4101303 | — | IC50 | = | 26950.0 | nM | 4.57 |
| CHEMBL4173562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4174452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4166141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4174056 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162692 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170614 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4172950 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162281 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4175814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4167954 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4167127 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162993 | — | IC50 | > | 10000.0 | nM | - |