Assay Detail
Functional
CHEMBL4146929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human NMUR1 expressed in HEK293 cells assessed as induction of IP3 levels using myo-[2-3H(N)]-inositol after 60 mins by SPA-based topcount assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of potent and proteolytically stable human neuromedin U receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 7.13 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169726 | — | — | 1 | 9.29 |
| CHEMBL4161902 | — | — | 1 | 8.80 |
| CHEMBL4177021 | — | — | 1 | 8.40 |
| CHEMBL4175546 | — | — | 1 | 8.38 |
| CHEMBL4165337 | — | — | 1 | 8.37 |
| CHEMBL4174679 | — | — | 1 | 8.29 |
| CHEMBL4165538 | — | — | 1 | 8.26 |
| CHEMBL4164922 | — | — | 1 | 8.11 |
| CHEMBL4175315 | — | — | 1 | 8.09 |
| CHEMBL4172552 | — | — | 1 | 7.98 |
| CHEMBL4168753 | — | — | 1 | 7.91 |
| CHEMBL4166161 | — | — | 1 | 7.73 |
| CHEMBL4169739 | — | — | 1 | 7.54 |
| CHEMBL3356083 | — | — | 1 | 7.41 |
| CHEMBL4160825 | — | — | 1 | 7.38 |
| CHEMBL4175953 | — | — | 1 | 7.29 |
| CHEMBL4164026 | — | — | 1 | 7.18 |
| CHEMBL4167677 | — | — | 1 | 7.11 |
| CHEMBL4169169 | — | — | 1 | 7.03 |
| CHEMBL4161501 | — | — | 1 | 7.03 |
| CHEMBL4169824 | — | — | 1 | 6.86 |
| CHEMBL4171697 | — | — | 1 | 6.76 |
| CHEMBL4172829 | — | — | 1 | 6.73 |
| CHEMBL4168351 | — | — | 1 | 6.72 |
| CHEMBL4162868 | — | — | 1 | 6.66 |
| CHEMBL4166325 | — | — | 1 | 6.64 |
| CHEMBL4176785 | — | — | 1 | 6.56 |
| CHEMBL4176945 | — | — | 1 | 6.56 |
| CHEMBL4172768 | — | — | 1 | 6.46 |
| CHEMBL4159176 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169726 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4161902 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4177021 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4175546 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4165337 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4174679 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4165538 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4164922 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4175315 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4172552 | — | EC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4168753 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL4166161 | — | EC50 | = | 18.6 | nM | 7.73 |
| CHEMBL4169739 | — | EC50 | = | 28.8 | nM | 7.54 |
| CHEMBL3356083 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL4160825 | — | EC50 | = | 41.4 | nM | 7.38 |
| CHEMBL4175953 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4164026 | — | EC50 | = | 65.8 | nM | 7.18 |
| CHEMBL4167677 | — | EC50 | = | 77.9 | nM | 7.11 |
| CHEMBL4161501 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4169169 | — | EC50 | = | 94.5 | nM | 7.03 |
| CHEMBL4169824 | — | EC50 | = | 138.9 | nM | 6.86 |
| CHEMBL4171697 | — | EC50 | = | 172.2 | nM | 6.76 |
| CHEMBL4172829 | — | EC50 | = | 184.9 | nM | 6.73 |
| CHEMBL4168351 | — | EC50 | = | 191.7 | nM | 6.72 |
| CHEMBL4162868 | — | EC50 | = | 216.6 | nM | 6.66 |
| CHEMBL4166325 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4176785 | — | EC50 | = | 274.6 | nM | 6.56 |
| CHEMBL4176945 | — | EC50 | = | 273.2 | nM | 6.56 |
| CHEMBL4172768 | — | EC50 | = | 343.4 | nM | 6.46 |
| CHEMBL4159176 | — | EC50 | = | 574.4 | nM | 6.24 |
| CHEMBL4161095 | — | EC50 | = | 593.7 | nM | 6.23 |
| CHEMBL4172327 | — | EC50 | = | 683.7 | nM | 6.17 |
| CHEMBL3356082 | — | EC50 | = | 709.4 | nM | 6.15 |
| CHEMBL4176206 | — | EC50 | = | 822.7 | nM | 6.08 |
| CHEMBL4169433 | — | EC50 | = | 1053.0 | nM | 5.98 |
| CHEMBL4161037 | — | EC50 | = | 2271.0 | nM | 5.64 |
| CHEMBL4164680 | — | EC50 | = | 3171.0 | nM | 5.50 |
| CHEMBL4173583 | — | EC50 | = | 5496.0 | nM | 5.26 |