Assay Detail
Functional
CHEMBL4147075
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Antiviral activity against Coxsackievirus B5 Ohio-1 ATCC VR 29 infected in African green monkey Vero 76 cells after 3 days by plaque reduction assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus B5 |
| Cell Type | Vero 76 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinoxaline derivatives as new inhibitors of coxsackievirus B5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29609 | PLECONARIL | 2.0 | 1 | 8.30 |
| CHEMBL4171360 | — | — | 1 | 7.22 |
| CHEMBL4163461 | — | — | 1 | 7.05 |
| CHEMBL4168581 | — | — | 1 | 6.52 |
| CHEMBL4160658 | — | — | 1 | 5.42 |
| CHEMBL4165162 | — | — | 1 | 4.25 |
| CHEMBL4170313 | — | — | 1 | - |
| CHEMBL4159682 | — | — | 1 | - |
| CHEMBL4173766 | — | — | 1 | - |
| CHEMBL4163061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29609 | PLECONARIL | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4171360 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4163461 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4168581 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4160658 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4165162 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL4170313 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL4159682 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4173766 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4163061 | — | EC50 | > | 100000.0 | nM | - |