Assay Detail
Binding
CHEMBL4148418
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Displacement of [3H]-8-OH-DPAT from human 5HT1AR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.48 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.70 |
| CHEMBL4170657 | — | — | 1 | 7.07 |
| CHEMBL4163778 | — | — | 1 | 7.00 |
| CHEMBL4166804 | — | — | 1 | 7.00 |
| CHEMBL4159967 | — | — | 1 | 6.96 |
| CHEMBL4170613 | — | — | 1 | 6.85 |
| CHEMBL4176588 | — | — | 1 | 6.74 |
| CHEMBL4176950 | — | — | 1 | 6.72 |
| CHEMBL4170484 | — | — | 1 | 6.71 |
| CHEMBL4171652 | — | — | 1 | 6.66 |
| CHEMBL4174055 | — | — | 1 | 6.52 |
| CHEMBL4162548 | — | — | 1 | 6.47 |
| CHEMBL4168743 | — | — | 1 | 6.38 |
| CHEMBL4162279 | — | — | 1 | 6.23 |
| CHEMBL4163626 | — | — | 1 | 5.65 |
| CHEMBL4174681 | — | — | 1 | 4.74 |
| CHEMBL4160262 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4170657 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL4163778 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4166804 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL4159967 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL4170613 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4176588 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL4176950 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4170484 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL4171652 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL4174055 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL4162548 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL4168743 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL4162279 | — | Ki | = | 585.0 | nM | 6.23 |
| CHEMBL4163626 | — | Ki | = | 2249.0 | nM | 5.65 |
| CHEMBL4174681 | — | Ki | = | 18290.0 | nM | 4.74 |
| CHEMBL4160262 | — | Ki | = | 18430.0 | nM | 4.73 |