Assay Detail
Binding
CHEMBL4148420
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Displacement of [3H]-prazosin from alpha1-adrenergic receptor in rat brain cortex after 30 mins by Microbeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.63 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.80 |
| CHEMBL4170657 | — | — | 1 | 6.78 |
| CHEMBL4170613 | — | — | 1 | 6.70 |
| CHEMBL4174055 | — | — | 1 | 6.60 |
| CHEMBL4159967 | — | — | 1 | 6.57 |
| CHEMBL4162279 | — | — | 1 | 6.56 |
| CHEMBL4168743 | — | — | 1 | 6.51 |
| CHEMBL4176950 | — | — | 1 | 6.30 |
| CHEMBL4166804 | — | — | 1 | 6.28 |
| CHEMBL4163778 | — | — | 1 | 6.23 |
| CHEMBL4162548 | — | — | 1 | - |
| CHEMBL4170484 | — | — | 1 | - |
| CHEMBL4174681 | — | — | 1 | - |
| CHEMBL4160262 | — | — | 1 | - |
| CHEMBL4176588 | — | — | 1 | - |
| CHEMBL4163626 | — | — | 1 | - |
| CHEMBL4171652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4170657 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL4170613 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4174055 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4159967 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL4162279 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL4168743 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL4176950 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4166804 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL4163778 | — | Ki | = | 587.0 | nM | 6.23 |
| CHEMBL4162548 | — | Ki | - | — | - | |
| CHEMBL4170484 | — | Ki | - | — | - | |
| CHEMBL4174681 | — | Ki | - | — | - | |
| CHEMBL4160262 | — | Ki | - | — | - | |
| CHEMBL4176588 | — | Ki | - | — | - | |
| CHEMBL4163626 | — | Ki | - | — | - | |
| CHEMBL4171652 | — | Ki | - | — | - |