Assay Detail
Functional
CHEMBL4148530
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Antiproliferative activity against human HL60 cells after 2 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.57 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165779 | — | — | 1 | 9.40 |
| CHEMBL4173698 | — | — | 1 | 8.74 |
| CHEMBL4177274 | — | — | 1 | 8.52 |
| CHEMBL4165993 | — | — | 1 | 8.43 |
| CHEMBL4167723 | — | — | 1 | 8.40 |
| CHEMBL4159494 | — | — | 1 | 8.40 |
| CHEMBL4171389 | — | — | 1 | 8.40 |
| CHEMBL330407 | — | — | 1 | 8.35 |
| CHEMBL4173388 | — | — | 1 | 8.31 |
| CHEMBL4167073 | — | — | 1 | 8.30 |
| CHEMBL4159163 | — | — | 1 | 8.25 |
| CHEMBL4172019 | — | — | 1 | 8.17 |
| CHEMBL4173924 | — | — | 1 | 7.87 |
| CHEMBL4175956 | — | — | 1 | 7.40 |
| CHEMBL4167049 | — | — | 1 | 7.30 |
| CHEMBL4161405 | — | — | 1 | 7.30 |
| CHEMBL4160752 | — | — | 1 | 7.28 |
| CHEMBL4161939 | — | — | 1 | 7.23 |
| CHEMBL4176195 | — | — | 1 | 7.22 |
| CHEMBL4161269 | — | — | 1 | 7.17 |
| CHEMBL4169211 | — | — | 1 | 7.16 |
| CHEMBL4177069 | — | — | 1 | 7.16 |
| CHEMBL4175841 | — | — | 1 | 6.65 |
| CHEMBL4175470 | — | — | 1 | 6.46 |
| CHEMBL4172465 | — | — | 1 | 6.33 |
| CHEMBL4172595 | — | — | 1 | 6.21 |
| CHEMBL4169423 | — | — | 1 | 6.11 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165779 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4173698 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4177274 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4165993 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4167723 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4159494 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4171389 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL330407 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4173388 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4167073 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4159163 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4172019 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4173924 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL4175956 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4167049 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4161405 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4160752 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4161939 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4176195 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4161269 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4169211 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4177069 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4175841 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL4175470 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4172465 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4172595 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4169423 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4000.0 | nM | 5.40 |