Assay Detail
ADMET
CHEMBL4148532
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Antiproliferative activity against HEK293 cells after 2 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.37 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4167723 | — | — | 1 | 8.48 |
| CHEMBL4172019 | — | — | 1 | 8.39 |
| CHEMBL330407 | — | — | 1 | 8.15 |
| CHEMBL4173698 | — | — | 1 | 8.15 |
| CHEMBL4177274 | — | — | 1 | 8.10 |
| CHEMBL4173388 | — | — | 1 | 8.09 |
| CHEMBL4165779 | — | — | 1 | 8.08 |
| CHEMBL4176195 | — | — | 1 | 7.88 |
| CHEMBL4177069 | — | — | 1 | 7.85 |
| CHEMBL4173924 | — | — | 1 | 7.84 |
| CHEMBL4159163 | — | — | 1 | 7.80 |
| CHEMBL4167073 | — | — | 1 | 7.72 |
| CHEMBL4161269 | — | — | 1 | 7.40 |
| CHEMBL4165993 | — | — | 1 | 7.39 |
| CHEMBL4171389 | — | — | 1 | 7.38 |
| CHEMBL4175956 | — | — | 1 | 7.24 |
| CHEMBL4175841 | — | — | 1 | 7.22 |
| CHEMBL4159494 | — | — | 1 | 7.19 |
| CHEMBL4161939 | — | — | 1 | 7.10 |
| CHEMBL4169211 | — | — | 1 | 7.01 |
| CHEMBL4167049 | — | — | 1 | 6.89 |
| CHEMBL4169423 | — | — | 1 | 6.85 |
| CHEMBL4160752 | — | — | 1 | 6.84 |
| CHEMBL4172595 | — | — | 1 | 6.82 |
| CHEMBL4175470 | — | — | 1 | 6.80 |
| CHEMBL4161405 | — | — | 1 | 6.73 |
| CHEMBL4172465 | — | — | 1 | 6.31 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4167723 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4172019 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL330407 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4173698 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4177274 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4173388 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4165779 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4176195 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4177069 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4173924 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL4159163 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4167073 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4161269 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4165993 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4171389 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL4175956 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4175841 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4159494 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4161939 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4169211 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4167049 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4169423 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4160752 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4172595 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4175470 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4161405 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4172465 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 25000.0 | nM | 4.60 |