Assay Detail
Binding
CHEMBL4148656
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Binding affinity to sigma-2 receptor (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.46 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 9.92 |
| CHEMBL227126 | — | — | 1 | 9.59 |
| CHEMBL53325 | — | — | 1 | 9.47 |
| CHEMBL4169075 | — | — | 1 | 8.29 |
| CHEMBL60048 | — | — | 1 | 7.99 |
| CHEMBL1188414 | — | — | 1 | 7.90 |
| CHEMBL4167498 | — | — | 1 | 7.50 |
| CHEMBL1215855 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL227126 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL53325 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL4169075 | — | Ki | = | 5.19 | nM | 8.29 |
| CHEMBL60048 | — | Ki | = | 10.33 | nM | 7.99 |
| CHEMBL1188414 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL4167498 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1215855 | — | Ki | = | 90.4 | nM | 7.04 |