Assay Detail
Binding
CHEMBL4148754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-AhxBak-OH binding to human 45-84/C37 Bcl-xL after 2 hrs by fluorescent polarization assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.42 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172616 | — | — | 1 | 6.82 |
| CHEMBL4162253 | — | — | 1 | 6.29 |
| CHEMBL4161200 | — | — | 1 | 6.08 |
| CHEMBL4176314 | — | — | 1 | 5.72 |
| CHEMBL4169123 | — | — | 1 | 5.66 |
| CHEMBL4177447 | — | — | 1 | 5.61 |
| CHEMBL4176611 | — | — | 1 | 5.56 |
| CHEMBL4174087 | — | — | 1 | 5.56 |
| CHEMBL4169534 | — | — | 1 | 5.41 |
| CHEMBL4177395 | — | — | 1 | 5.36 |
| CHEMBL4175537 | — | — | 1 | 5.28 |
| CHEMBL4161959 | — | — | 1 | 5.08 |
| CHEMBL4165700 | — | — | 1 | 5.07 |
| CHEMBL4168747 | — | — | 1 | 5.00 |
| CHEMBL4175134 | — | — | 1 | 4.85 |
| CHEMBL4171691 | — | — | 1 | 4.81 |
| CHEMBL4164915 | — | — | 1 | 4.78 |
| CHEMBL4167271 | — | — | 1 | 4.68 |
| CHEMBL4160437 | — | — | 1 | - |
| CHEMBL4168346 | — | — | 1 | - |
| CHEMBL4166826 | — | — | 1 | - |
| CHEMBL4162625 | — | — | 1 | - |
| CHEMBL4160019 | — | — | 1 | - |
| CHEMBL4163814 | — | — | 1 | - |
| CHEMBL4163377 | — | — | 1 | - |
| CHEMBL4170660 | — | — | 1 | - |
| CHEMBL4171694 | — | — | 1 | - |
| CHEMBL4167274 | — | — | 1 | - |
| CHEMBL4175138 | — | — | 1 | - |
| CHEMBL4163818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172616 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4162253 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL4161200 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL4176314 | — | Ki | = | 1910.0 | nM | 5.72 |
| CHEMBL4169123 | — | Ki | = | 2190.0 | nM | 5.66 |
| CHEMBL4177447 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL4176611 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL4174087 | — | Ki | = | 2730.0 | nM | 5.56 |
| CHEMBL4169534 | — | Ki | = | 3920.0 | nM | 5.41 |
| CHEMBL4177395 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL4175537 | — | Ki | = | 5310.0 | nM | 5.28 |
| CHEMBL4161959 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL4165700 | — | Ki | = | 8480.0 | nM | 5.07 |
| CHEMBL4168747 | — | Ki | = | 9910.0 | nM | 5.00 |
| CHEMBL4175134 | — | Ki | = | 14080.0 | nM | 4.85 |
| CHEMBL4171691 | — | Ki | = | 15630.0 | nM | 4.81 |
| CHEMBL4164915 | — | Ki | = | 16470.0 | nM | 4.78 |
| CHEMBL4167271 | — | Ki | = | 20730.0 | nM | 4.68 |
| CHEMBL4160437 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4168346 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4166826 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4162625 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4160019 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4163814 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4163377 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4170660 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4171694 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4167274 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4175138 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4163818 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4172927 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4159296 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4167208 | — | Ki | > | 23000.0 | nM | - |