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Assay Detail

CHEMBL4149563

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Intermediate

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces.
Gui C, Yuan J, Mo X, Huang H, Zhang S, Gu YC, Ju J.
J Nat Prod (2018) 81 : 1278 -1289
PubMed 29767975 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.45 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4162306 1 6.70
CHEMBL4174260 1 6.52
CHEMBL417 EPIRUBICIN 4.0 1 6.40
CHEMBL4165745 1 5.85
CHEMBL4162509 1 5.51
CHEMBL4169773 1 5.44
CHEMBL4165946 1 5.30
CHEMBL4176359 1 5.27
CHEMBL4173197 1 5.24
CHEMBL4177443 1 5.22
CHEMBL4159124 1 5.21
CHEMBL4171788 1 5.14
CHEMBL22025 1 5.02
CHEMBL4163996 1 5.01
CHEMBL4160317 1 4.88
CHEMBL4166355 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4162306 IC50 = 200.0 nM 6.70
CHEMBL4174260 IC50 = 300.0 nM 6.52
CHEMBL417 EPIRUBICIN IC50 = 400.0 nM 6.40
CHEMBL4165745 IC50 = 1400.0 nM 5.85
CHEMBL4162509 IC50 = 3100.0 nM 5.51
CHEMBL4169773 IC50 = 3600.0 nM 5.44
CHEMBL4165946 IC50 = 5000.0 nM 5.30
CHEMBL4176359 IC50 = 5400.0 nM 5.27
CHEMBL4173197 IC50 = 5800.0 nM 5.24
CHEMBL4177443 IC50 = 6000.0 nM 5.22
CHEMBL4159124 IC50 = 6100.0 nM 5.21
CHEMBL4171788 IC50 = 7200.0 nM 5.14
CHEMBL22025 IC50 = 9600.0 nM 5.02
CHEMBL4163996 IC50 = 9800.0 nM 5.01
CHEMBL4160317 IC50 = 13200.0 nM 4.88
CHEMBL4166355 IC50 = 32800.0 nM 4.48