Assay Detail
Functional
CHEMBL4149733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant rat N-terminal FLAG/eYFP-fused GPR35 expressed in HEK293 cells assessed as induction of beta-arrestin recruitment by BRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
G protein-coupled receptor GPR35 (CHEMBL2390812) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
SAR Studies of N-[2-(1H-Tetrazol-5-yl)phenyl]benzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.02 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201198 | PEMIROLAST | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201198 | PEMIROLAST | EC50 | = | 95.0 | nM | 7.02 |