Assay Detail
Binding
CHEMBL4149863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL311) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.37 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4111330 | — | — | 1 | 8.85 |
| CHEMBL4115628 | — | — | 1 | 8.85 |
| CHEMBL3892956 | — | — | 1 | 8.40 |
| CHEMBL4115649 | — | — | 1 | 8.37 |
| CHEMBL4170867 | — | — | 1 | 8.36 |
| CHEMBL4168402 | — | — | 1 | 8.11 |
| CHEMBL4161899 | — | — | 1 | 8.08 |
| CHEMBL3911371 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4111330 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4115628 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3892956 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4115649 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4170867 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL4168402 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4161899 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL3911371 | — | Ki | = | 11.0 | nM | 7.96 |