Assay Detail
Binding
CHEMBL4149969
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Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknown origin) by NMR based FAXS analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 4.28 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161639 | — | — | 1 | 4.70 |
| CHEMBL4163988 | — | — | 1 | 4.46 |
| CHEMBL4174337 | — | — | 1 | 4.30 |
| CHEMBL4176772 | — | — | 1 | 4.30 |
| CHEMBL4161222 | — | — | 1 | 4.10 |
| CHEMBL4166600 | — | — | 1 | 4.10 |
| CHEMBL4168539 | — | — | 1 | 4.00 |
| CHEMBL4171835 | — | — | 1 | - |
| CHEMBL4176751 | — | — | 1 | - |
| CHEMBL4159632 | — | — | 1 | - |
| CHEMBL4170258 | — | — | 1 | - |
| CHEMBL4176735 | — | — | 1 | - |
| CHEMBL4169870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161639 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL4163988 | — | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL4174337 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL4176772 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL4161222 | — | Kd | = | 80000.0 | nM | 4.10 |
| CHEMBL4166600 | — | Kd | = | 80000.0 | nM | 4.10 |
| CHEMBL4168539 | — | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL4171835 | — | Kd | < | 10000.0 | nM | - |
| CHEMBL4176751 | — | Kd | = | 160000.0 | nM | - |
| CHEMBL4159632 | — | Kd | = | 220000.0 | nM | - |
| CHEMBL4170258 | — | Kd | = | 120000.0 | nM | - |
| CHEMBL4176735 | — | Kd | = | 680000.0 | nM | - |
| CHEMBL4169870 | — | Kd | = | 170000.0 | nM | - |