Assay Detail
Binding
CHEMBL4149970
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Inhibition of recombinant complement factor D catalytic domain (unknown origin) using Z-Lys-thiobenzyl as substrate pretreated for 1 hr followed by substrate addition by 2,4-dinitrobenzenesulfonyl-2,7-desmethyl-fluorescein probe based spectrofluorimetric thioesterolysis assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.47 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171835 | — | — | 1 | 5.47 |
| CHEMBL4076148 | — | — | 1 | 4.85 |
| CHEMBL4176772 | — | — | 1 | 4.70 |
| CHEMBL4168539 | — | — | 1 | 4.37 |
| CHEMBL4174337 | — | — | 1 | 4.36 |
| CHEMBL4161639 | — | — | 1 | 4.27 |
| CHEMBL4169870 | — | — | 1 | 4.12 |
| CHEMBL4163988 | — | — | 1 | 4.08 |
| CHEMBL4161222 | — | — | 1 | 4.01 |
| CHEMBL4176735 | — | — | 1 | - |
| CHEMBL4170258 | — | — | 1 | - |
| CHEMBL4159632 | — | — | 1 | - |
| CHEMBL4176751 | — | — | 1 | - |
| CHEMBL4166600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171835 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4076148 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4176772 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4168539 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4174337 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4161639 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4169870 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL4163988 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4161222 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL4176735 | — | IC50 | = | 690000.0 | nM | - |
| CHEMBL4170258 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL4159632 | — | IC50 | = | 257000.0 | nM | - |
| CHEMBL4176751 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL4166600 | — | IC50 | = | 310000.0 | nM | - |