Assay Detail
Functional
CHEMBL4149975
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Agonist activity at human NMUR1 expressed in HEK293 cells assessed as IP3 accumulation after 60 mins in presence of myo-[2-3H(N)]inositol by scintillation proximity assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.40 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169726 | — | — | 1 | 9.29 |
| CHEMBL4162728 | — | — | 1 | 8.54 |
| CHEMBL4170275 | — | — | 1 | 8.43 |
| CHEMBL4159554 | — | — | 1 | 7.96 |
| CHEMBL4164987 | — | — | 1 | 7.72 |
| CHEMBL4162351 | — | — | 1 | 7.54 |
| CHEMBL3356083 | — | — | 1 | 7.41 |
| CHEMBL4173224 | — | — | 1 | 7.27 |
| CHEMBL4167803 | — | — | 1 | 7.24 |
| CHEMBL4161479 | — | — | 1 | 6.81 |
| CHEMBL4175581 | — | — | 1 | 6.07 |
| CHEMBL4171236 | — | — | 1 | 5.99 |
| CHEMBL4164957 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169726 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4162728 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4170275 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4159554 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4164987 | — | EC50 | = | 18.9 | nM | 7.72 |
| CHEMBL4162351 | — | EC50 | = | 28.5 | nM | 7.54 |
| CHEMBL3356083 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL4173224 | — | EC50 | = | 53.3 | nM | 7.27 |
| CHEMBL4167803 | — | EC50 | = | 57.2 | nM | 7.24 |
| CHEMBL4161479 | — | EC50 | = | 155.7 | nM | 6.81 |
| CHEMBL4175581 | — | EC50 | = | 843.0 | nM | 6.07 |
| CHEMBL4171236 | — | EC50 | = | 1028.0 | nM | 5.99 |
| CHEMBL4164957 | — | EC50 | = | 1314.0 | nM | 5.88 |