Assay Detail
Binding
CHEMBL4150189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.93 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163641 | — | — | 1 | 6.30 |
| CHEMBL551842 | LOBARIC ACID | — | 1 | 6.10 |
| CHEMBL4174317 | — | — | 1 | 6.05 |
| CHEMBL558886 | — | — | 1 | 5.82 |
| CHEMBL563581 | SAKISACAULON A | — | 1 | 5.77 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163641 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL551842 | LOBARIC ACID | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4174317 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL558886 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL563581 | SAKISACAULON A | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL265502 | SURAMIN | IC50 | = | 2900.0 | nM | 5.54 |