Assay Detail
Functional
CHEMBL4150586
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Antiproliferative activity against human HL60 cells after 48 hrs by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.14 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175555 | — | — | 1 | 5.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.82 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 5.43 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.43 |
| CHEMBL4160840 | — | — | 1 | 5.21 |
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 5.08 |
| CHEMBL4167685 | — | — | 1 | 4.96 |
| CHEMBL4167286 | — | — | 1 | 4.92 |
| CHEMBL4164238 | — | — | 1 | 4.80 |
| CHEMBL4078477 | — | — | 1 | 4.66 |
| CHEMBL4160833 | — | — | 1 | 4.43 |
| CHEMBL4168763 | — | — | 1 | - |
| CHEMBL4168767 | — | — | 1 | - |
| CHEMBL4159366 | — | — | 1 | - |
| CHEMBL4162254 | — | — | 1 | - |
| CHEMBL4175964 | — | — | 1 | - |
| CHEMBL4165344 | — | — | 1 | - |
| CHEMBL4172110 | — | — | 1 | - |
| CHEMBL4168707 | — | — | 1 | - |
| CHEMBL4169802 | — | — | 1 | - |
| CHEMBL4170168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175555 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL4160840 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4167685 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4167286 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4164238 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4078477 | — | IC50 | = | 21710.0 | nM | 4.66 |
| CHEMBL4160833 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4168763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4168767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4159366 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4162254 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4175964 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4165344 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4172110 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4168707 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4169802 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4170168 | — | IC50 | > | 50000.0 | nM | - |