Assay Detail
Binding
CHEMBL4150666
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Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) neuraminidase H274Y mutant activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Anhui/1/2005(H5N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.66 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.17 |
| CHEMBL3342485 | — | — | 1 | 6.80 |
| CHEMBL4161935 | — | — | 1 | 6.41 |
| CHEMBL4175983 | — | — | 1 | 6.18 |
| CHEMBL4163386 | — | — | 1 | 5.83 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.79 |
| CHEMBL4172581 | — | — | 1 | 5.47 |
| CHEMBL4173256 | — | — | 1 | 5.30 |
| CHEMBL4168794 | — | — | 1 | 5.03 |
| CHEMBL4165368 | — | — | 1 | 5.00 |
| CHEMBL4174094 | — | — | 1 | 4.90 |
| CHEMBL4162570 | — | — | 1 | 4.42 |
| CHEMBL4166014 | — | — | 1 | 4.33 |
| CHEMBL4160858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 6.71 | nM | 8.17 |
| CHEMBL3342485 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4161935 | — | IC50 | = | 387.07 | nM | 6.41 |
| CHEMBL4175983 | — | IC50 | = | 663.9 | nM | 6.18 |
| CHEMBL4163386 | — | IC50 | = | 1485.67 | nM | 5.83 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4172581 | — | IC50 | = | 3365.67 | nM | 5.47 |
| CHEMBL4173256 | — | IC50 | = | 5007.0 | nM | 5.30 |
| CHEMBL4168794 | — | IC50 | = | 9387.0 | nM | 5.03 |
| CHEMBL4165368 | — | IC50 | = | 10028.33 | nM | 5.00 |
| CHEMBL4174094 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL4162570 | — | IC50 | = | 38083.33 | nM | 4.42 |
| CHEMBL4166014 | — | IC50 | = | 46686.67 | nM | 4.33 |
| CHEMBL4160858 | — | IC50 | > | 100000.0 | nM | - |