Assay Detail
Functional
CHEMBL4151165
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Antiproliferative activity against human A2058 cells after 7 days by cell-titer glo based luminescence assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2058 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.89 | 7.89 |
| Imax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168754 | — | — | 2 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168754 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4168754 | — | Imax | = | 96.0 | % | - |