Assay Detail
Binding
CHEMBL4151512
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Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux incubated for 5 mins by fluorescence based assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Quinolone resistance protein NorA (CHEMBL5114) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.28 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171147 | — | — | 1 | 5.96 |
| CHEMBL4175014 | — | — | 1 | 5.80 |
| CHEMBL4172225 | — | — | 1 | 5.75 |
| CHEMBL4163342 | — | — | 1 | 5.55 |
| CHEMBL4170066 | — | — | 1 | 5.42 |
| CHEMBL4169284 | — | — | 1 | 5.42 |
| CHEMBL4164426 | — | — | 1 | 5.41 |
| CHEMBL4161736 | — | — | 1 | 5.40 |
| CHEMBL4175717 | — | — | 1 | 5.39 |
| CHEMBL4162146 | — | — | 1 | 5.39 |
| CHEMBL4162139 | — | — | 1 | 5.38 |
| CHEMBL4176162 | — | — | 1 | 5.37 |
| CHEMBL4168943 | — | — | 1 | 5.34 |
| CHEMBL4174957 | — | — | 1 | 5.33 |
| CHEMBL4172372 | — | — | 1 | 5.33 |
| CHEMBL4164737 | — | — | 1 | 5.33 |
| CHEMBL4167074 | — | — | 1 | 5.31 |
| CHEMBL4172781 | — | — | 1 | 5.26 |
| CHEMBL4168315 | — | — | 1 | 5.14 |
| CHEMBL4170063 | — | — | 1 | 5.09 |
| CHEMBL1651180 | — | — | 1 | 5.05 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.04 |
| CHEMBL4169246 | — | — | 1 | 5.03 |
| CHEMBL4171241 | — | — | 1 | 5.00 |
| CHEMBL4169390 | — | — | 1 | 4.92 |
| CHEMBL4164881 | — | — | 1 | 4.86 |
| CHEMBL4176869 | — | — | 1 | 4.81 |
| CHEMBL4161319 | — | — | 1 | 4.72 |
| CHEMBL4173506 | — | — | 1 | - |
| CHEMBL4172633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171147 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4175014 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4172225 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4163342 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4170066 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4169284 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4164426 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4161736 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4175717 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4162146 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4162139 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4176162 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4168943 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4164737 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4172372 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4174957 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4167074 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4172781 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4168315 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4170063 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1651180 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL772 | RESERPINE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4169246 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4171241 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4169390 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4164881 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4176869 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4161319 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL4160603 | — | IC50 | - | — | - | |
| CHEMBL4176571 | — | IC50 | - | — | - | |
| CHEMBL4165958 | — | IC50 | - | — | - | |
| CHEMBL4161465 | — | IC50 | - | — | - | |
| CHEMBL4172302 | — | IC50 | - | — | - | |
| CHEMBL4169005 | — | IC50 | - | — | - | |
| CHEMBL4171219 | — | IC50 | - | — | - | |
| CHEMBL4165580 | — | IC50 | - | — | - | |
| CHEMBL4173512 | — | IC50 | - | — | - | |
| CHEMBL4165585 | — | IC50 | - | — | - | |
| CHEMBL4163206 | — | IC50 | - | — | - | |
| CHEMBL4173927 | — | IC50 | - | — | - | |
| CHEMBL4166649 | — | IC50 | - | — | - | |
| CHEMBL4177278 | — | IC50 | - | — | - | |
| CHEMBL4172633 | — | IC50 | - | — | - | |
| CHEMBL4173506 | — | IC50 | - | — | - |