Assay Detail
Binding
CHEMBL4151595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of ATPase activity of ABCG2 (unknown origin) expressed in High Five insect cell membranes by ascorbic acid ammonia molybdate reaction based colorimetry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.95 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163310 | — | — | 1 | 8.00 |
| CHEMBL4174458 | — | — | 1 | 7.54 |
| CHEMBL4167604 | — | — | 1 | 7.32 |
| CHEMBL4171017 | — | — | 1 | 7.20 |
| CHEMBL4164155 | — | — | 1 | 6.95 |
| CHEMBL4163784 | — | — | 1 | 6.49 |
| CHEMBL4174412 | — | — | 1 | 6.16 |
| CHEMBL4167361 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163310 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4174458 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4167604 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4171017 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4164155 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4163784 | — | EC50 | = | 326.0 | nM | 6.49 |
| CHEMBL4174412 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4167361 | — | EC50 | = | 1230.0 | nM | 5.91 |