Assay Detail
Binding
CHEMBL4151747
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Binding affinity to ERalpha (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164133 | — | — | 1 | 8.55 |
| CHEMBL4175085 | — | — | 1 | 8.29 |
| CHEMBL4159656 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164133 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4175085 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4159656 | — | IC50 | = | 136.0 | nM | 6.87 |