Assay Detail
Functional
CHEMBL4151773
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Protection against cisplatin-induced toxicity in P3 mouse cochlear explants assessed as increase in outer hair cell count incubated for 24 hrs by phalloidin staining based confocal microscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Spiral organ of cochlea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.45 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 8.30 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.60 |
| CHEMBL457177 | — | — | 1 | 7.55 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.82 |
| CHEMBL409450 | 6BIO | — | 1 | 6.24 |
| CHEMBL411491 | — | — | 1 | 6.00 |
| CHEMBL1094304 | OLOMOUCINE II | — | 1 | 5.52 |
| CHEMBL258805 | SU-9516 | 1.0 | 1 | 5.22 |
| CHEMBL4162724 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488436 | AZD-5438 | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL445813 | AT-7519 | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL457177 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL296586 | KENPAULLONE | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL409450 | 6BIO | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL411491 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1094304 | OLOMOUCINE II | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL258805 | SU-9516 | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4162724 | — | EC50 | = | 15000.0 | nM | 4.82 |