Assay Detail
Binding
CHEMBL4152129
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Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Kelch-like ECH-associated protein 1 (CHEMBL2069156) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 6.96 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237245 | — | — | 1 | 7.70 |
| CHEMBL3632711 | — | — | 1 | 7.36 |
| CHEMBL4166445 | — | — | 1 | 6.99 |
| CHEMBL4174651 | — | — | 1 | 6.99 |
| CHEMBL2402207 | — | — | 1 | 5.77 |
| CHEMBL4166048 | — | — | 1 | - |
| CHEMBL4173296 | — | — | 1 | - |
| CHEMBL4162602 | — | — | 1 | - |
| CHEMBL4169869 | — | — | 1 | - |
| CHEMBL4159226 | — | — | 1 | - |
| CHEMBL4174360 | — | — | 1 | - |
| CHEMBL4176664 | — | — | 1 | - |
| CHEMBL4176126 | — | — | 1 | - |
| CHEMBL3600957 | — | — | 1 | - |
| CHEMBL3632890 | — | — | 1 | - |
| CHEMBL4160703 | — | — | 1 | - |
| CHEMBL4171299 | — | — | 1 | - |
| CHEMBL4166752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237245 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3632711 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL4166445 | — | Kd | = | 103.0 | nM | 6.99 |
| CHEMBL4174651 | — | Kd | = | 102.0 | nM | 6.99 |
| CHEMBL2402207 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL4166048 | — | Kd | - | — | - | |
| CHEMBL4173296 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL4162602 | — | Kd | - | — | - | |
| CHEMBL4169869 | — | Kd | - | — | - | |
| CHEMBL4159226 | — | Kd | - | — | - | |
| CHEMBL4174360 | — | Kd | - | — | - | |
| CHEMBL4176664 | — | Kd | - | — | - | |
| CHEMBL4176126 | — | Kd | - | — | - | |
| CHEMBL3600957 | — | Kd | - | — | - | |
| CHEMBL3632890 | — | Kd | - | — | - | |
| CHEMBL4160703 | — | Kd | - | — | - | |
| CHEMBL4171299 | — | Kd | - | — | - | |
| CHEMBL4166752 | — | Kd | - | — | - |