Assay Detail
Functional
CHEMBL4152860
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Growth inhibition of human SU-DHL1 cells after 3 days by luminescence-based CellTiter-Glo assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SU-DHL-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 4 | - | - |
| IC50 | 3 | 7.55 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.82 |
| CHEMBL4161454 | — | — | 2 | 7.48 |
| CHEMBL4165519 | — | — | 2 | 7.34 |
| CHEMBL4159122 | — | — | 1 | - |
| CHEMBL4169769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4161454 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4165519 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4165519 | — | GI | - | — | - | |
| CHEMBL4161454 | — | GI | - | — | - | |
| CHEMBL4159122 | — | GI | - | — | - | |
| CHEMBL4169769 | — | GI | - | — | - |