Assay Detail
Binding
CHEMBL4152874
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Inhibition of BTK (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.39 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301625 | SPEBRUTINIB | 2.0 | 1 | 9.15 |
| CHEMBL3979355 | — | — | 1 | 8.89 |
| CHEMBL3702836 | — | — | 1 | 8.72 |
| CHEMBL1230541 | — | — | 1 | 8.72 |
| CHEMBL4172284 | — | — | 1 | 8.70 |
| CHEMBL4175428 | — | — | 1 | 8.66 |
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | 8.52 |
| CHEMBL4167139 | — | — | 1 | 8.40 |
| CHEMBL2057918 | — | — | 1 | 8.40 |
| CHEMBL4162057 | — | — | 1 | 8.23 |
| CHEMBL3263640 | — | — | 1 | 8.10 |
| CHEMBL4163691 | POSELTINIB | 2.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301625 | SPEBRUTINIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3979355 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3702836 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1230541 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4172284 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4175428 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3707348 | ACALABRUTINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4167139 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2057918 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4162057 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3263640 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4163691 | POSELTINIB | IC50 | = | 651.95 | nM | 6.19 |