Assay Detail
Functional
CHEMBL4153271
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Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.46 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1224773 | — | — | 1 | 6.00 |
| CHEMBL379849 | — | — | 1 | 5.89 |
| CHEMBL4168285 | — | — | 1 | 5.85 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.85 |
| CHEMBL4165251 | — | — | 1 | 5.77 |
| CHEMBL4175483 | — | — | 1 | 5.72 |
| CHEMBL2386417 | — | — | 1 | 5.40 |
| CHEMBL4167818 | — | — | 1 | 5.19 |
| CHEMBL2386414 | — | — | 1 | 5.18 |
| CHEMBL249697 | BMS-345541 | — | 1 | 5.10 |
| CHEMBL4159907 | — | — | 1 | 5.07 |
| CHEMBL2386418 | — | — | 1 | 4.99 |
| CHEMBL2386411 | — | — | 1 | 4.95 |
| CHEMBL4160381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1224773 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL379849 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4168285 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL140 | CURCUMIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4165251 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4175483 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2386417 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4167818 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2386414 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL249697 | BMS-345541 | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4159907 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2386418 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2386411 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4160381 | — | IC50 | > | 60000.0 | nM | - |