Assay Detail
Binding
CHEMBL4153706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights into serotonin receptor ligands polypharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.89 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164250 | — | — | 1 | 5.31 |
| CHEMBL4177293 | — | — | 1 | 5.21 |
| CHEMBL4174845 | — | — | 1 | 5.21 |
| CHEMBL4162688 | — | — | 1 | 5.15 |
| CHEMBL4164143 | — | — | 1 | 5.04 |
| CHEMBL1613157 | — | — | 1 | 4.81 |
| CHEMBL4160177 | — | — | 1 | 4.50 |
| CHEMBL4175296 | — | — | 1 | 4.43 |
| CHEMBL4170813 | — | — | 1 | 4.38 |
| CHEMBL4166092 | — | — | 1 | - |
| CHEMBL4166667 | — | — | 1 | - |
| CHEMBL4174981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164250 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL4177293 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL4174845 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL4162688 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL4164143 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL1613157 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL4160177 | — | Ki | = | 31400.0 | nM | 4.50 |
| CHEMBL4175296 | — | Ki | = | 36800.0 | nM | 4.43 |
| CHEMBL4170813 | — | Ki | = | 41800.0 | nM | 4.38 |
| CHEMBL4166092 | — | Ki | = | 330400.0 | nM | - |
| CHEMBL4166667 | — | Ki | = | 195600.0 | nM | - |
| CHEMBL4174981 | — | Ki | = | 284100.0 | nM | - |