Assay Detail
Binding
CHEMBL4153940
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Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in presence of FMN/FAD by liquid scintillation counting method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.50 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161447 | — | — | 1 | 7.24 |
| CHEMBL107251 | 1400W | — | 1 | 7.00 |
| CHEMBL4171271 | — | — | 1 | 6.77 |
| CHEMBL4169004 | — | — | 1 | 6.60 |
| CHEMBL4160671 | — | — | 1 | 6.56 |
| CHEMBL4169649 | — | — | 1 | 6.35 |
| CHEMBL4177347 | — | — | 1 | 6.35 |
| CHEMBL4173076 | — | — | 1 | 6.27 |
| CHEMBL4176848 | — | — | 1 | 5.99 |
| CHEMBL4166234 | — | — | 1 | 5.91 |
| CHEMBL4171523 | — | — | 1 | - |
| CHEMBL4163633 | — | — | 1 | - |
| CHEMBL4161080 | — | — | 1 | - |
| CHEMBL4172371 | — | — | 1 | - |
| CHEMBL4164493 | — | — | 1 | - |
| CHEMBL4170892 | — | — | 1 | - |
| CHEMBL4162963 | — | — | 1 | - |
| CHEMBL4160751 | — | — | 1 | - |
| CHEMBL4171037 | — | — | 1 | - |
| CHEMBL4161718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161447 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL107251 | 1400W | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4171271 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4169004 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL4160671 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4169649 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL4177347 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4173076 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL4176848 | — | IC50 | = | 1025.0 | nM | 5.99 |
| CHEMBL4166234 | — | IC50 | = | 1229.0 | nM | 5.91 |
| CHEMBL4171523 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4163633 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4161080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4172371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4164493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170892 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4160751 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4171037 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4161718 | — | IC50 | > | 10000.0 | nM | - |