Assay Detail
Binding
CHEMBL4154431
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Inhibition of BRD4 (unknown origin) by Alphascreen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.87 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4177351 | — | — | 1 | 7.11 |
| CHEMBL3410002 | — | — | 1 | 6.85 |
| CHEMBL2179387 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4177351 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3410002 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2179387 | — | IC50 | = | 220.0 | nM | 6.66 |