Assay Detail
Functional
CHEMBL4155097
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Cytotoxicity against human KU812 cells assessed as reduction in cell viability after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KU812 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.69 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 6.22 |
| CHEMBL4177432 | — | — | 1 | 4.41 |
| CHEMBL4163110 | — | — | 1 | 4.38 |
| CHEMBL4170635 | — | — | 1 | 4.24 |
| CHEMBL4174068 | — | — | 1 | 4.20 |
| CHEMBL4166554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4177432 | — | EC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL4163110 | — | EC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL4170635 | — | EC50 | = | 57300.0 | nM | 4.24 |
| CHEMBL4174068 | — | EC50 | = | 63800.0 | nM | 4.20 |
| CHEMBL4166554 | — | EC50 | = | 177500.0 | nM | - |