Assay Detail
Functional
CHEMBL4155441
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Antagonist activity at Smo receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159710 | — | — | 1 | 8.00 |
| CHEMBL2031273 | — | — | 1 | 6.80 |
| CHEMBL2031084 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159710 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2031273 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2031084 | — | IC50 | = | 650.0 | nM | 6.19 |