Assay Detail
Functional
CHEMBL4155548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against amastigote stage of Leishmania donovani MHOM/IN/00/DEVI infected in human THP1 cells assessed as inhibition of parasite infection after 120 hrs by Giemsa staining-based microscopic method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.47 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.40 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.27 |
| CHEMBL4170207 | — | — | 1 | 4.75 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4170207 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1631694 | FEXINIDAZOLE | IC50 | > | 50000.0 | nM | - |