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Assay Detail

CHEMBL4155553

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against wild type trypomastigote stage of Trypanosoma brucei brucei S427 assessed as parasite growth inhibition after 72 hrs by haemocytometer
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Pedron J, Boudot C, Hutter S, Bourgeade-Delmas S, Stigliani JL, Sournia-Saquet A, Moreau A, Boutet-Robinet E, Paloque L, Mothes E, Laget M, Vendier L, Pratviel G, Wyllie S, Fairlamb A, Azas N, Courtioux B, Valentin A, Verhaeghe P.
Eur J Med Chem (2018) 155 : 135 -152
PubMed 29885575 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.75 4.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4170207 1 4.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4170207 IC50 = 17700.0 nM 4.75