Assay Detail
Binding
CHEMBL4155897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FLT4 by Hotspot assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 3 (CHEMBL1955) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the selective and efficacious inhibitors of FLT3 mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.16 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.48 |
| CHEMBL4075720 | — | — | 1 | 8.35 |
| CHEMBL4163870 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 3.27 | nM | 8.48 |
| CHEMBL4075720 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4163870 | — | IC50 | = | 23.01 | nM | 7.64 |