Assay Detail
Binding
CHEMBL4155968
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Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux measured over 5 mins by fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Quinolone resistance protein NorA (CHEMBL5114) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.25 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4177330 | — | — | 1 | 5.66 |
| CHEMBL4164053 | — | — | 1 | 5.48 |
| CHEMBL4171010 | — | — | 1 | 5.48 |
| CHEMBL4175374 | — | — | 1 | 5.36 |
| CHEMBL4168471 | — | — | 1 | 5.30 |
| CHEMBL4167087 | — | — | 1 | 5.28 |
| CHEMBL4170494 | — | — | 1 | 5.24 |
| CHEMBL1651181 | — | — | 1 | 5.14 |
| CHEMBL4164750 | — | — | 1 | 5.14 |
| CHEMBL4160250 | — | — | 1 | 5.06 |
| CHEMBL1651180 | — | — | 1 | 5.05 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.04 |
| CHEMBL4174235 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4177330 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4164053 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4171010 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4175374 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4168471 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4167087 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4170494 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1651181 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4164750 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4160250 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1651180 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL772 | RESERPINE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4174235 | — | IC50 | = | 10600.0 | nM | 4.97 |