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Assay Detail

CHEMBL4156004

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel pyrimidinic selenourea induces DNA damage, cell cycle arrest, and apoptosis in human breast carcinoma.
Barbosa FAR, Siminski T, Canto RFS, Almeida GM, Mota NSRS, Ourique F, Pedrosa RC, Braga AL.
Eur J Med Chem (2018) 155 : 503 -515
PubMed 29908443 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.63 5.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4164911 1 5.41
CHEMBL4171324 1 5.06
CHEMBL4175529 1 4.88
CHEMBL4171211 1 4.60
CHEMBL236789 MONASTROL 1 4.23
CHEMBL185 FLUOROURACIL 4.0 1 4.20
CHEMBL240050 1 4.03
CHEMBL4169886 1 -
CHEMBL4170555 1 -
CHEMBL4162615 1 -
CHEMBL4176680 1 -
CHEMBL4166063 1 -
CHEMBL4161563 1 -
CHEMBL4169484 1 -
CHEMBL4174771 1 -
CHEMBL4171682 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4164911 IC50 = 3900.0 nM 5.41
CHEMBL4171324 IC50 = 8800.0 nM 5.06
CHEMBL4175529 IC50 = 13100.0 nM 4.88
CHEMBL4171211 IC50 = 25200.0 nM 4.60
CHEMBL236789 MONASTROL IC50 = 59100.0 nM 4.23
CHEMBL185 FLUOROURACIL IC50 = 63000.0 nM 4.20
CHEMBL240050 IC50 = 92900.0 nM 4.03
CHEMBL4169886 IC50 = 452200.0 nM -
CHEMBL4170555 IC50 = 175800.0 nM -
CHEMBL4162615 IC50 = 207100.0 nM -
CHEMBL4176680 IC50 = 200600.0 nM -
CHEMBL4166063 IC50 = 301000.0 nM -
CHEMBL4161563 IC50 = 169400.0 nM -
CHEMBL4169484 IC50 = 247800.0 nM -
CHEMBL4174771 IC50 = 251700.0 nM -
CHEMBL4171682 IC50 = 181100.0 nM -