Compound Detail
CHEMBL240050
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL240050 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BBTBTECFWXDPNI-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
339.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 4.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kinesin-like protein KIF11 CHEMBL4581 | IC50 | 4.94 | 4.79 | 11500.0 | 2 |
| MCF7 CHEMBL387 | IC50 | 4.03 | 4.03 | 92900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kinesin-like protein KIF11 | IC50 | = | 11500.0 | nM | 4.94 | Inhibition of Eg5 ATPase activity expressed in Escherichia coli after 12 hrs | 17587586 |
| Kinesin-like protein KIF11 | IC50 | = | 23000.0 | nM | 4.64 | Inhibition of microtubule-stimulated Eg5 ATPase activity expressed in Escherichi... | 17587586 |
| MCF7 | IC50 | = | 92900.0 | nM | 4.03 | Cytotoxicity against human MCF7 cells assessed as decrease in cell viability aft... | 29908443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17587586 | 10.1016/j.bmc.2007.06.016 | HeLa | 3 |
| 17587586 | 10.1016/j.bmc.2007.06.016 | Kinesin-like protein KIF11 | 2 |
| 29908443 | 10.1016/j.ejmech.2018.06.026 | MCF7 | 1 |
| 29908443 | 10.1016/j.ejmech.2018.06.026 | HeLa | 1 |
| 29908443 | 10.1016/j.ejmech.2018.06.026 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine