Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL897635

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of microtubule-stimulated Eg5 ATPase activity expressed in Escherichia coli after 12 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Kinesin-like protein KIF11 (CHEMBL4581)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New chemical tools for investigating human mitotic kinesin Eg5.
Klein E, DeBonis S, Thiede B, Skoufias DA, Kozielski F, Lebeau L.
Bioorg Med Chem (2007) 15 : 6474 -6488
PubMed 17587586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.66 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL240471 1 5.52
CHEMBL236181 1 5.26
CHEMBL236179 1 4.94
CHEMBL236789 MONASTROL 1 4.91
CHEMBL240689 1 4.74
CHEMBL235974 1 4.68
CHEMBL240050 1 4.64
CHEMBL392146 1 4.62
CHEMBL427676 1 4.20
CHEMBL394879 1 4.16
CHEMBL397799 1 4.14
CHEMBL397171 1 4.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL240471 IC50 = 3000.0 nM 5.52
CHEMBL236181 IC50 = 5500.0 nM 5.26
CHEMBL236179 IC50 = 11500.0 nM 4.94
CHEMBL236789 MONASTROL IC50 = 12300.0 nM 4.91
CHEMBL240689 IC50 = 18300.0 nM 4.74
CHEMBL235974 IC50 = 21000.0 nM 4.68
CHEMBL240050 IC50 = 23000.0 nM 4.64
CHEMBL392146 IC50 = 24000.0 nM 4.62
CHEMBL427676 IC50 = 62500.0 nM 4.20
CHEMBL394879 IC50 = 69100.0 nM 4.16
CHEMBL397799 IC50 = 72200.0 nM 4.14
CHEMBL397171 IC50 = 82300.0 nM 4.08