Assay Detail
Binding
CHEMBL4156167
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Inhibition of bovine beta-trypsin using Boc-QAR-MCA as substrate measured every 30 secs for 10 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.96 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164510 | — | — | 1 | 10.34 |
| CHEMBL4172393 | — | — | 1 | 10.21 |
| CHEMBL4167071 | — | — | 1 | 9.77 |
| CHEMBL4170662 | — | — | 1 | 9.64 |
| CHEMBL4162159 | — | — | 1 | 7.09 |
| CHEMBL4175285 | — | — | 1 | 6.71 |
| CHEMBL453539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164510 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL4172393 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL4167071 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL4170662 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4162159 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL4175285 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL453539 | — | Ki | = | 0.008 | nM | - |