Assay Detail
Binding
CHEMBL4156496
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Binding affinity to recombinant human carbonic anhydrase 4 (19 to 284 residues) expressed in mammalian expression system in presence of ANS by fluorescent thermal shift assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 17 | 6.76 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173471 | — | — | 1 | 8.15 |
| CHEMBL4166964 | — | — | 1 | 8.00 |
| CHEMBL4165570 | — | — | 1 | 7.65 |
| CHEMBL4162133 | — | — | 1 | 7.30 |
| CHEMBL4166643 | — | — | 1 | 7.30 |
| CHEMBL4160149 | — | — | 1 | 7.08 |
| CHEMBL4168997 | — | — | 1 | 6.96 |
| CHEMBL4165896 | — | — | 1 | 6.96 |
| CHEMBL4173501 | — | — | 1 | 6.78 |
| CHEMBL4175740 | — | — | 1 | 6.58 |
| CHEMBL4168586 | — | — | 1 | 6.55 |
| CHEMBL4173814 | — | — | 1 | 6.48 |
| CHEMBL4172331 | — | — | 1 | 6.40 |
| CHEMBL4165127 | — | — | 1 | 5.93 |
| CHEMBL120886 | — | — | 1 | 5.82 |
| CHEMBL4160627 | — | — | 1 | 5.48 |
| CHEMBL4177268 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173471 | — | Kd | = | 7.14 | nM | 8.15 |
| CHEMBL4166964 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4165570 | — | Kd | = | 22.2 | nM | 7.65 |
| CHEMBL4162133 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL4166643 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL4160149 | — | Kd | = | 83.3 | nM | 7.08 |
| CHEMBL4168997 | — | Kd | = | 111.0 | nM | 6.96 |
| CHEMBL4165896 | — | Kd | = | 111.0 | nM | 6.96 |
| CHEMBL4173501 | — | Kd | = | 167.0 | nM | 6.78 |
| CHEMBL4175740 | — | Kd | = | 263.0 | nM | 6.58 |
| CHEMBL4168586 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL4173814 | — | Kd | = | 333.0 | nM | 6.48 |
| CHEMBL4172331 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL4165127 | — | Kd | = | 1170.0 | nM | 5.93 |
| CHEMBL120886 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL4160627 | — | Kd | = | 3330.0 | nM | 5.48 |
| CHEMBL4177268 | — | Kd | = | 3820.0 | nM | 5.42 |