Assay Detail
Binding
CHEMBL4156499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 6 (21 to 290 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 5.54 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165570 | — | — | 1 | 6.84 |
| CHEMBL4160149 | — | — | 1 | 6.78 |
| CHEMBL4166643 | — | — | 1 | 6.54 |
| CHEMBL4175740 | — | — | 1 | 6.30 |
| CHEMBL4166964 | — | — | 1 | 6.23 |
| CHEMBL4172331 | — | — | 1 | 6.20 |
| CHEMBL4173471 | — | — | 1 | 6.00 |
| CHEMBL4165896 | — | — | 1 | 6.00 |
| CHEMBL4162133 | — | — | 1 | 5.93 |
| CHEMBL4168997 | — | — | 1 | 5.93 |
| CHEMBL4168586 | — | — | 1 | 5.84 |
| CHEMBL4173501 | — | — | 1 | 5.84 |
| CHEMBL4173814 | — | — | 1 | 5.84 |
| CHEMBL4176862 | — | — | 1 | 5.48 |
| CHEMBL120886 | — | — | 1 | 5.40 |
| CHEMBL4170371 | — | — | 1 | 5.25 |
| CHEMBL4168966 | — | — | 1 | 5.18 |
| CHEMBL4165127 | — | — | 1 | 5.11 |
| CHEMBL4162451 | — | — | 1 | 5.00 |
| CHEMBL4170792 | — | — | 1 | 4.90 |
| CHEMBL4174214 | — | — | 1 | 4.78 |
| CHEMBL4159066 | — | — | 1 | 4.70 |
| CHEMBL4163518 | — | — | 1 | 4.70 |
| CHEMBL4165543 | — | — | 1 | 4.60 |
| CHEMBL4176828 | — | — | 1 | 4.48 |
| CHEMBL4160627 | — | — | 1 | 4.11 |
| CHEMBL4177268 | — | — | 1 | - |
| CHEMBL4170058 | — | — | 1 | - |
| CHEMBL4161701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165570 | — | Kd | = | 143.0 | nM | 6.84 |
| CHEMBL4160149 | — | Kd | = | 167.0 | nM | 6.78 |
| CHEMBL4166643 | — | Kd | = | 286.0 | nM | 6.54 |
| CHEMBL4175740 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4166964 | — | Kd | = | 588.0 | nM | 6.23 |
| CHEMBL4172331 | — | Kd | = | 625.0 | nM | 6.20 |
| CHEMBL4173471 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL4165896 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL4162133 | — | Kd | = | 1180.0 | nM | 5.93 |
| CHEMBL4168997 | — | Kd | = | 1180.0 | nM | 5.93 |
| CHEMBL4168586 | — | Kd | = | 1430.0 | nM | 5.84 |
| CHEMBL4173501 | — | Kd | = | 1430.0 | nM | 5.84 |
| CHEMBL4173814 | — | Kd | = | 1430.0 | nM | 5.84 |
| CHEMBL4176862 | — | Kd | = | 3330.0 | nM | 5.48 |
| CHEMBL120886 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL4170371 | — | Kd | = | 5560.0 | nM | 5.25 |
| CHEMBL4168966 | — | Kd | = | 6670.0 | nM | 5.18 |
| CHEMBL4165127 | — | Kd | = | 7690.0 | nM | 5.11 |
| CHEMBL4162451 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL4170792 | — | Kd | = | 12500.0 | nM | 4.90 |
| CHEMBL4174214 | — | Kd | = | 16700.0 | nM | 4.78 |
| CHEMBL4159066 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL4163518 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL4165543 | — | Kd | = | 25000.0 | nM | 4.60 |
| CHEMBL4176828 | — | Kd | = | 33300.0 | nM | 4.48 |
| CHEMBL4160627 | — | Kd | = | 77500.0 | nM | 4.11 |
| CHEMBL4177268 | — | Kd | = | 200000.0 | nM | - |
| CHEMBL4170058 | — | Kd | = | 200000.0 | nM | - |
| CHEMBL4161701 | — | Kd | = | 200000.0 | nM | - |