Assay Detail
Binding
CHEMBL4156500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal His-tagged human carbonic anhydrase 7 (3 to 264 residues) expressed in Escherichia coli BL21 (DE3) strain in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 6.92 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165570 | — | — | 1 | 8.30 |
| CHEMBL4160149 | — | — | 1 | 8.30 |
| CHEMBL4166643 | — | — | 1 | 8.18 |
| CHEMBL4172331 | — | — | 1 | 8.00 |
| CHEMBL4173471 | — | — | 1 | 8.00 |
| CHEMBL4166964 | — | — | 1 | 7.96 |
| CHEMBL4162133 | — | — | 1 | 7.78 |
| CHEMBL4168997 | — | — | 1 | 7.78 |
| CHEMBL4175740 | — | — | 1 | 7.72 |
| CHEMBL4165896 | — | — | 1 | 7.70 |
| CHEMBL4173501 | — | — | 1 | 7.54 |
| CHEMBL4173814 | — | — | 1 | 7.48 |
| CHEMBL4170792 | — | — | 1 | 7.18 |
| CHEMBL4168586 | — | — | 1 | 7.18 |
| CHEMBL120886 | — | — | 1 | 6.96 |
| CHEMBL4165127 | — | — | 1 | 6.90 |
| CHEMBL4176862 | — | — | 1 | 6.90 |
| CHEMBL4170371 | — | — | 1 | 6.90 |
| CHEMBL4168966 | — | — | 1 | 6.65 |
| CHEMBL4163518 | — | — | 1 | 6.30 |
| CHEMBL4165543 | — | — | 1 | 5.84 |
| CHEMBL4159066 | — | — | 1 | 5.70 |
| CHEMBL4162451 | — | — | 1 | 5.54 |
| CHEMBL4176828 | — | — | 1 | 5.48 |
| CHEMBL4160627 | — | — | 1 | 5.18 |
| CHEMBL4174214 | — | — | 1 | 4.78 |
| CHEMBL4161701 | — | — | 1 | 4.60 |
| CHEMBL4177268 | — | — | 1 | - |
| CHEMBL4170058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165570 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4160149 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4166643 | — | Kd | = | 6.67 | nM | 8.18 |
| CHEMBL4172331 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4173471 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4166964 | — | Kd | = | 11.1 | nM | 7.96 |
| CHEMBL4162133 | — | Kd | = | 16.7 | nM | 7.78 |
| CHEMBL4168997 | — | Kd | = | 16.7 | nM | 7.78 |
| CHEMBL4175740 | — | Kd | = | 19.2 | nM | 7.72 |
| CHEMBL4165896 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4173501 | — | Kd | = | 28.6 | nM | 7.54 |
| CHEMBL4173814 | — | Kd | = | 33.3 | nM | 7.48 |
| CHEMBL4170792 | — | Kd | = | 66.7 | nM | 7.18 |
| CHEMBL4168586 | — | Kd | = | 66.7 | nM | 7.18 |
| CHEMBL120886 | — | Kd | = | 111.0 | nM | 6.96 |
| CHEMBL4165127 | — | Kd | = | 125.0 | nM | 6.90 |
| CHEMBL4176862 | — | Kd | = | 125.0 | nM | 6.90 |
| CHEMBL4170371 | — | Kd | = | 125.0 | nM | 6.90 |
| CHEMBL4168966 | — | Kd | = | 226.0 | nM | 6.65 |
| CHEMBL4163518 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4165543 | — | Kd | = | 1430.0 | nM | 5.84 |
| CHEMBL4159066 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL4162451 | — | Kd | = | 2860.0 | nM | 5.54 |
| CHEMBL4176828 | — | Kd | = | 3330.0 | nM | 5.48 |
| CHEMBL4160627 | — | Kd | = | 6670.0 | nM | 5.18 |
| CHEMBL4174214 | — | Kd | = | 16700.0 | nM | 4.78 |
| CHEMBL4161701 | — | Kd | = | 25000.0 | nM | 4.60 |
| CHEMBL4177268 | — | Kd | = | 200000.0 | nM | - |
| CHEMBL4170058 | — | Kd | = | 200000.0 | nM | - |